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Interferon lambda genetic polymorphisms and viral infection: the tip of the iceberg?

DNA and cell biology - 1 Feb 2014

Russell Clark D, Griffiths Samantha J, Haas Jürgen

Abstract excerpt

Pathogen-host interaction studies have demonstrated the importance of host factors in the pathogenesis of infectious disease. An emerging theme is that polymorphisms in the genes encoding these factors can influence the host response to infection and the course of disease. Genetic variation affecting interferon lambda (IFN-λ) expression is now known to influence the outcome of both hepatitis C virus and herpes...

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PMID: 24329419
DOI: 10.1089/dna.2013.2261

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