Article
A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jan 2018
Ranlund Siri, Calafato Stella, Thygesen Johan H, Lin Kuang, Cahn Wiepke, Crespo-Facorro Benedicto, de Zwarte Sonja M C, Díez Álvaro, Di Forti Marta, Iyegbe Conrad, Jablensky Assen, Jones Rebecca, Hall Mei-Hua, Kahn Rene, Kalaydjieva Luba, Kravariti Eugenia, McDonald Colm, McIntosh Andrew M, McQuillin Andrew, Picchioni Marco, Prata Diana P, Rujescu Dan, Schulze Katja, Shaikh Madiha, Toulopoulou Timothea, van Haren Neeltje, van Os Jim, Vassos Evangelos, Walshe Muriel, Lewis Cathryn, Murray Robin M, Powell John, Bramon Elvira
Abstract excerpt
This large multi-center study investigates the relationships between genetic risk for schizophrenia and bipolar disorder, and multi-modal endophenotypes for psychosis. The sample included 4,242 individuals; 1,087 patients with psychosis, 822 unaffected first-degree relatives of patients, and 2,333 controls. Endophenotypes included the P300 event-related potential (N = 515), lateral ventricular volume (N = 798),...
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