Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endophenotype-Informed Association Analyses for Liver Fat Accumulation and Metabolic Dysfunction in the Fels Longitudinal Study.

International journal of molecular sciences - 17 May 2025

Garza Ariana L, Blangero John, Lee Miryoung, Bauer Cici X, Czerwinski Stefan A, Choh Audrey C

Abstract excerpt

The identification of causal genomic regions for liver fat accumulation in the context of metabolic dysfunction remains a challenging goal. This study aimed to identify potential endophenotypes for liver fat content and employ them in bivariate linkage searches for pleiotropic genetic regions where targeted association analysis is more likely to reveal significant variants. Multiple metabolic risk and adiposity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adiposity
Share to Endophenotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Linkage

Share to Insulin Resistance

Share to Intra-Abdominal Fat

Share to Longitudinal Studies

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 40429953
DOI: 10.3390/ijms26104812
PMCID: PMC12112654

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endophenotype-Informed Association Analyses for Liver Fat Accumulation and Metabolic Dysfunction in the Fels Longitudinal Study.PMID 40429953Read ↗

Cross-ancestry genome-wide association studies of liver function biomarkers uncover pleiotropic variants, systemic disease links and therapeutic targets.Semantic proximity Read ↗

Genetic Mapping of Multiple Traits Identifies Novel Genes for Adiposity, Lipids, and Insulin Secretory Capacity in Outbred Rats.Semantic proximity Read ↗

Genetic mapping of multiple metabolic traits identifies novel genes for adiposity, lipids and insulin secretory capacity in outbred ratsSemantic proximity Read ↗

Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks.Semantic proximity Read ↗

Genetic correlations between liver fat content, metabolic health, and adiposity distribution in the Fels Longitudinal Study.Semantic proximity Read ↗

Genome-wide analysis of hepatic lipid content in extreme obesity.Semantic proximity Read ↗

Shared genetic architecture of obesity and gastroesophageal reflux disease.Semantic proximity Read ↗

Using endophenotypes for pathway clusters to map complex disease genes.Semantic proximity Read ↗

Mini-Review: The Contribution of Intermediate Phenotypes to GxE Effects on Disorders of Body Composition in the New OMICS Era.Semantic proximity Read ↗

QTL-mapping in the obese Berlin Fat Mouse identifies additional candidate genes for obesity and fatty liver diseaseSemantic proximity Read ↗

Topological analysis of metabolic networks integrating co-segregating transcriptomes and metabolomes in type 2 diabetic rat congenic series.Semantic proximity Read ↗

Epistatic Networks Associated with Parent-of-Origin Effects on Metabolic TraitsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.