Article
Mini-Review: The Contribution of Intermediate Phenotypes to GxE Effects on Disorders of Body Composition in the New OMICS Era.
International journal of environmental research and public health - 17 Sept 2017
Nava-Gonzalez Edna J, Gallegos-Cabriales Esther C, Leal-Berumen Irene, Bastarrachea Raul A
Abstract excerpt
Studies of gene-environment (GxE) interactions describe how genetic and environmental factors influence the risk of developing disease. Intermediate (molecular or clinical) phenotypes (IPs) are traits or metabolic biomarkers that mediate the effects of gene-environment influences on risk behaviors. Functional systems genomics discovery offers mechanistic insights into how DNA variations affect IPs in order to...
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