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Proteome-wide mendelian randomization identifies novel therapeutic targets for chronic kidney disease.

Scientific reports - 27 Sept 2024

Zhao Pin, Li Zhenhao, Xue Shilong, Cui Jinshan, Zhan Yonghao, Zhu Zhaowei, Zhang Xuepei

Abstract excerpt

There is an urgent need to pinpoint novel targets for drug discovery in the context of chronic kidney disease (CKD), and the proteome represents a significant pool of potential therapeutic targets. To address this, we performed proteome-wide analyses using Mendelian randomization (MR) and colocalization techniques to uncover potential targets for CKD. We extracted summary-level data from the ARIC study, focusing...

Topics

Humans
Genetic Predisposition to Disease
Genome-Wide Association Study
Glomerular Filtration Rate
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide
Proteome
Renal Insufficiency, Chronic
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Identifiers

PMID: 39333727
DOI: 10.1038/s41598-024-72970-3
PMCID: PMC11437114

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