Back to search

Article

Identification of therapeutic targets for chronic kidney disease through Mendelian randomization analysis of druggable genes

2024-10-23

Abstract excerpt

<title>Abstract</title> <p>BACKGROUND Chronic Kidney Disease (CKD) is a multifaceted and gradually advancing condition characterized by a complex pathogenesis. The current therapeutic options for CKD remain limited in efficacy. Consequently, the identification and exploration of novel drug targets for CKD are of paramount importance. METHODS We identified cis-expression quantitative trait loci (cis-eQTLs) with...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
a1e51937-9683-5db4-b42f-f59f1b3c9484
DOI
10.21203/rs.3.rs-5088380/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Identification of therapeutic targets for chronic kidney disease through Mendelian randomization analysis of druggable genesDOI 10.21203/rs.3.rs-5088380/v1
Comprehensive Druggable Genome-Wide Mendelian Randomization Reveals Therapeutic Targets for Kidney DiseasesSemantic proximity
Proteome-wide mendelian randomization identifies novel therapeutic targets for chronic kidney disease.Semantic proximity
Identification of Therapeutic Targets for Hyperuricemia: Systematic Genome-Wide Mendelian Randomization and Colocalization AnalysisSemantic proximity
Identification of druggable targets in acute kidney injury by proteome- and transcriptome-wide Mendelian randomization and bioinformatics analysisSemantic proximity
Therapeutic Targets for Diabetic Kidney Disease: Proteome-Wide Mendelian Randomization and Colocalization Analyses.Semantic proximity
Systematic prioritization of potential therapeutic targets for glomerulonephritis using multi-omics Mendelian randomization.Semantic proximity
Multi-Scalar Data Integration Decoding Risk Genes for Chronic Kidney DiseaseSemantic proximity
Screening for potential biological markers of chronic kidney disease based on WGCNA and machine learningSemantic proximity
The Use of Genomics to Drive Kidney Disease Drug Discovery and Development.Semantic proximity
Potential drug targets for tumors identified through Mendelian randomization analysis.Semantic proximity
Integrative Bioinformatics Analysis Provides Insight into the Molecular Mechanisms of Chronic Kidney DiseaseSemantic proximity
Genetically proxied therapeutic inhibition of kidney function drug targets and type 2 diabetes in Africans: A Mendelian randomization studySemantic proximity
Select a neighboring publication to make it the new centre.