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Article

Comprehensive mutational analysis of the sequence-function relationship within a viral internal ribosome entry site.

Nucleic acids research - 22 May 2025

Grunseich Sabrina G, Strobel Scott A

Abstract excerpt

The cricket paralysis virus (CrPV) intergenic region internal ribosome entry site (IRES) binds to the ribosome without the need for any initiation factors. Their length, simple mechanism, and ability to function in diverse cell-free systems make CrPV-like IRESs useful tools to study the mechanism of translation and to express proteins. We report the use of a RelE-based next-generation sequencing method,...

Read the complete abstract on PubMed

Topics

Internal Ribosome Entry Sites
Dicistroviridae
Ribosomes
Mutation
RNA, Viral
Nucleic Acid Conformation
High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Peptide Chain Initiation, Translational

Base Sequence

Source

Open in PubMed Open full text

Identifiers

PMID: 40421802
DOI: 10.1093/nar/gkaf445
PMCID: PMC12107430

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