Article
Naturally occurring dicistronic cricket paralysis virus RNA is regulated by two internal ribosome entry sites.
Molecular and cellular biology - 1 Jul 2000
Wilson J E, Powell M J, Hoover S E, Sarnow P
Abstract excerpt
Cricket paralysis virus is a member of a group of insect picorna-like viruses. Cloning and sequencing of the single plus-strand RNA genome revealed the presence of two nonoverlapping open reading frames, ORF1 and ORF2, that encode the nonstructural and structural proteins, respectively. We show that each ORF is preceded by one internal ribosome entry site (IRES). The intergenic IRES is located 6,024 nucleotides...
Topics
- Animals
- Base Sequence
- Codon, Initiator
- Gene Expression Regulation, Viral
- Genome, Viral
- Interspersed Repetitive Sequences
- Molecular Sequence Data
- Mutation
- Open Reading Frames
- Picornaviridae
- Plant Extracts
- Protein Biosynthesis
- RNA, Viral
- Regulatory Sequences, Nucleic Acid