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Article

Human variation and risk assessment: microarray and other studies utilizing human hepatocytes and human liver subcellular preparations.

Journal of biochemical and molecular toxicology - 1 Jan 2014

Hodgson Ernest, Wallace Andrew D, Shah Ruchir R, Choi Kyoungju, Joo Hyun

Abstract excerpt

The new paradigms proposed for human health risk assessment stress the need for the use of human and human-derived cell lines, and this review summarizes the use of primary human hepatocytes and hepatocyte subcellular preparations for the investigation of the metabolism and metabolic interactions of environmental chemicals. This includes interactions based on inhibition, induction, and activation. The role of...

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Identifiers

PMID: 24272995
DOI: 10.1002/jbt.21534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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