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Identification of genetic loci shared between schizophrenia and the Big Five personality traits.

Scientific reports - 22 May 2017

Smeland Olav B, Wang Yunpeng, Lo Min-Tzu, Li Wen, Frei Oleksandr, Witoelar Aree, Tesli Martin, Hinds David A, Tung Joyce Y, Djurovic Srdjan, Chen Chi-Hua, Dale Anders M, Andreassen Ole A

Abstract excerpt

Schizophrenia is associated with differences in personality traits, and recent studies suggest that personality traits and schizophrenia share a genetic basis. Here we aimed to identify specific genetic loci shared between schizophrenia and the Big Five personality traits using a Bayesian statistical framework. Using summary statistics from genome-wide association studies (GWAS) on personality traits in the...

Topics

Genetic Association Studies
Genetic Loci
Genetic Predisposition to Disease
Humans
Personality
Polymorphism, Single Nucleotide
Quantitative Trait, Heritable
Schizophrenia
Schizophrenic Psychology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28533504
DOI: 10.1038/s41598-017-02346-3
PMCID: PMC5440373

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