Article
Polygenic risk for schizophrenia and schizotypal traits in non-clinical subjects.
Psychological medicine - 1 Apr 2022
Nenadić Igor, Meller Tina, Schmitt Simon, Stein Frederike, Brosch Katharina, Mosebach Johannes, Ettinger Ulrich, Grant Phillip, Meinert Susanne, Opel Nils, Lemke Hannah, Fingas Stella, Förster Katharina, Hahn Tim, Jansen Andreas, Andlauer Till F M, Forstner Andreas J, Heilmann-Heimbach Stefanie, Hall Alisha S M, Awasthi Swapnil, Ripke Stephan, Witt Stephanie H, Rietschel Marcella, Müller-Myhsok Bertram, Nöthen Markus M, Dannlowski Udo, Krug Axel, Streit Fabian, Kircher Tilo
Abstract excerpt
BACKGROUND: Schizotypy is a putative risk phenotype for psychosis liability, but the overlap of its genetic architecture with schizophrenia is poorly understood. METHODS: We tested the hypothesis that dimensions of schizotypy (assessed with the SPQ-B) are associated with a polygenic risk score (PRS) for schizophrenia in a sample of 623 psychiatrically healthy, non-clinical subjects from the FOR2107 multi-centre...
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