Epidemiological and molecular evaluation of BRAF, KRAS, NRAS genes and MSI in the development of colorectal cancer.

doi:10.1016/j.gene.2023.147395

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Article

Epidemiological and molecular evaluation of BRAF, KRAS, NRAS genes and MSI in the development of colorectal cancer.

Gene - 20 Jun 2023

Paula Simedan Vila Ana, Helena Rodrigues Gabriela, Leite Marzochi Ludmila, Garcia de Oliveira-Cucolo Juliana, Lívia Silva Galbiatti-Dias Ana, Felipe Maciel Andrade Rafael, de Santi Neto Dalísio, Gomes Netinho João, Castiglioni Lilian, Cristina Pavarino Érika, Maria Goloni-Bertollo Eny

Abstract excerpt

BACKGROUND AND OBJECTIVES: KRAS, NRAS, BRAF mutations and microsatellite instability (MSI) can be associated with Colorectal Cancer (CRC) development. MATERIAL AND METHODS: We evaluated 828 medical records of CRC patients from a school hospital from January/2016 to December/2020. Variables such a...

Topics

Humans
Male
Middle Aged
Female
Proto-Oncogene Proteins B-raf
Microsatellite Instability
Colorectal Neoplasms
Proto-Oncogene Proteins p21(ras)
Genes, ras
Mutation
Membrane Proteins
GTP Phosphohydrolases

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Open in PubMed

Identifiers

PMID: 36990254
DOI: 10.1016/j.gene.2023.147395

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-36990254-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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