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Article

Selected cell receptor genotypes differentially modulate the ABO blood group influence on Factor VIII levels in severe aortic stenosis.

Thrombosis research - 1 Jul 2025

Lunghi Barbara, Castagna Annalisa, Branchini Alessio, Baroni Marcello, Marchetti Giovanna, Mazzoni Gianni, Legnani Cristina, Spizzo Marianna, Mango Gabriele, Friso Simonetta, Martinelli Nicola, Bernardi Francesco

Abstract excerpt

BACKGROUND: Altered blood flow, which characterizes aortic stenosis (AS), influences von Willebrand factor (VWF) conformation and enhances ADAMTS13 cleavage, potentially influencing factor VIII (FVIII) clearance and plasma levels. AIM: To investigate whether ABO blood group and genetic variants of cellular receptors involved in VWF/FVIII clearance may interact with AS in determining genotype-driven FVIII levels....

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Topics

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Share to ABO Blood-Group System
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40398046
DOI: 10.1016/j.thromres.2025.109356

Genes

ABO
LDLR
STAB2
VWF
ASGR2
CAD
CLEC4M
ADAMTS13
SCARA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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