Interleukin-6 receptor Asp358Ala gene polymorphism is associated with plasma C-reactive protein levels and severity of aortic valve stenosis.

doi:10.1515/cclm-2013-0606

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Article

Interleukin-6 receptor Asp358Ala gene polymorphism is associated with plasma C-reactive protein levels and severity of aortic valve stenosis.

Clinical chemistry and laboratory medicine - 1 Jul 2014

Wypasek Ewa, Potaczek Daniel P, Lamplmayr Markus, Sadowski Jerzy, Undas Anetta

Abstract excerpt

BACKGROUND: Interleukin-6 receptor (IL-6R) gene Asp358Ala (A>C, rs2228145) polymorphism has been associated with lower circulating inflammation biomarkers in coronary artery disease (CAD), such as C-reactive protein (CRP) or fibrinogen, but its role in the pathogenesis of aortic valve stenosis (AS) remains unknown. Since the pathogenesis of AS and atherosclerosis shares several similarities, we tested the...

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PMID: 24717336
DOI: 10.1515/cclm-2013-0606

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