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Altered DNA methylation of the ABO gene is associated with differential plasma levels of von willebrand factor and E‐selectin

22 Aug 2025

Abstract excerpt

BACKGROUND: The ABO blood group system is associated with differential susceptibility to thrombotic vascular diseases. ABO is also known to be a strong trans-protein quantitative trait locus for plasma proteins involved in cell adhesion and hemostasis. STUDY DESIGN AND METHOD: To further investigate these associations, we integrated epigenomic, genomic, and proteomic data from the Milieu Intérieur cohort. We used...

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PMID: 40845133
DOI: 10.1111/trf.18342

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