Article
Genome-Wide Association Study Identifies That the ABO Blood Group System Influences Interleukin-10 Levels and the Risk of Clinical Events in Patients with Acute Coronary Syndrome.
PloS one - 1 Jan 2015
Johansson Åsa, Alfredsson Jenny, Eriksson Niclas, Wallentin Lars, Siegbahn Agneta
Abstract excerpt
INTRODUCTION: Acute coronary syndrome (ACS) is a major cause of mortality worldwide. We have previously shown that increased interleukin-10 (IL-10) levels are associated with poor outcome in ACS patients. METHOD: We performed a genome-wide association study in 2864 ACS patients and 408 healthy controls, to identify genetic variants associated with IL-10 levels. Then haplotype analyses of the identified loci were...
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