Article
Crohn's and Parkinson's Disease-Associated LRRK2 Mutations Alter Type II Interferon Responses in Human CD14+ Blood Monocytes Ex Vivo.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology - 1 Dec 2020
Ikezu Tsuneya, Koro Lacin, Wolozin Benjamin, Farraye Francis A, Strongosky Audrey J, Wszolek Zbigniew K
Abstract excerpt
The Leucine Rich Repeat Kinase 2 (LRRK2) is one of causative genes of familial Parkinson's disease (PD). The M2397T polymorphism in LRRK2 is genetically associated with sporadic Crohn's disease (CD). LRRK2 is expressed in human CD14+ monocytes, induced by interferon-γ (IFN-γ) and suppresses inflammatory activation. We hypothesize that IFN-γ-induced LRRK2 and inflammatory gene expression is altered by LRRK2...
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