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DNA methylation signature of a lifestyle-based resilience index for cognitive health

22 Apr 2025

Abstract excerpt

Cognitive resilience (CR) contributes to the variability in risk for developing and progressing in Alzheimer's disease (AD) among individuals. Beyond genetics, recent studies highlight the critical role of lifestyle factors in enhancing CR and delaying cognitive decline. DNA methylation (DNAm), an epigenetic mechanism influenced by both genetic and environmental factors, including CR-related lifestyle factors,...

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PMID: 40264239
DOI: 10.1186/s13195-025-01733-7

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