Article
Generation of Hoxa11-3XFLAG and Hoxd11-3XFLAG alleles to investigate Hox11 genome-wide binding.
Developmental biology - 1 Aug 2025
Echevarría-Andino Martha L, Song Jane Y, van Ginkel Paul R, Chen Shuyang, Flynn Corey G K, Keleş Sündüz, Allen Benjamin L, Wellik Deneen M
Abstract excerpt
Hox genes encode for evolutionary conserved transcription factors that direct the proper development of the body plan. Despite decades of research, little is known regarding their downstream target genes, especially in vertebrates. The strong evolutionary conservation of their DNA-binding homeodomain, their generic AT-rich binding sites, and the lack of specific antibodies has precluded rigorous examination. To...
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