Article
Generation of FLAG-tagged Arx knock-in mouse model.
Genesis (New York, N.Y. : 2000) - 1 Jul 2022
Lim Youngshin, Cho Il-Taeg, Golden Jeffrey A, Cho Ginam
Abstract excerpt
The Aristaless-related homeobox (ARX) is a paired-like homeodomain transcription factor playing important roles in brain development. Patients with mutations in ARX have a spectrum of neurodevelopmental disorders such as epilepsy, intellectual disability, and autism spectrum disorder, with or without structural abnormalities of the brain such as lissencephaly (smooth brain), microcephaly (small brain), and/or...
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