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Article

Concordance between Tumor Tissue and Plasma DNA Genotyping in the NCI-MATCH Trial (EAY131).

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2025

Gouda Mohamed A, Janku Filip, Yuan Ying, Drusbosky Leylah M, Chen Alice P, Zheng Xiaofeng, Patel Keyur, Hamilton Stanley R, Routbort Mark, Tricoli James V, Williams P Mickey, Iafrate A John, Sklar Jeffrey, Coffey Brent, Little Richard F, Arteaga Carlos L, O'Dwyer Peter J, Flaherty Keith T, Harris Lyndsay N, Meric-Bernstam Funda

Abstract excerpt

PURPOSE: Liquid biopsies with circulating tumor DNA (ctDNA) analysis are increasingly being utilized as a noninvasive approach to identify actionable genomic alterations in advanced/metastatic cancers. In this study, we report the correlation between ctDNA analysis of plasma samples collected from patients enrolled in the NCI-MATCH trial and tumor tissue-based sequencing. EXPERIMENTAL DESIGN: We analyzed plasma...

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Identifiers

PMID: 40388547
DOI: 10.1158/1078-0432.CCR-24-3531
PMCID: PMC12383705

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