Validation of a Plasma-Based Comprehensive Cancer Genotyping Assay Utilizing Orthogonal Tissue- and Plasma-Based Methodologies.

doi:10.1158/1078-0432.CCR-17-3831

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Article

Validation of a Plasma-Based Comprehensive Cancer Genotyping Assay Utilizing Orthogonal Tissue- and Plasma-Based Methodologies.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2018

Odegaard Justin I, Vincent John J, Mortimer Stefanie, Vowles James V, Ulrich Bryan C, Banks Kimberly C, Fairclough Stephen R, Zill Oliver A, Sikora Marcin, Mokhtari Reza, Abdueva Diana, Nagy Rebecca J, Lee Christine E, Kiedrowski Lesli A, Paweletz Cloud P, Eltoukhy Helmy, Lanman Richard B, Chudova Darya I, Talasaz AmirAli

Abstract excerpt

Purpose: To analytically and clinically validate a circulating cell-free tumor DNA sequencing test for comprehensive tumor genotyping and demonstrate its clinical feasibility.Experimental Design: Analytic validation was conducted according to established principles and guidelines. Blood-to-blood clinical validation comprised blinded external comparison with clinical droplet digital PCR across 222 consecutive...

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PMID: 29691297
DOI: 10.1158/1078-0432.CCR-17-3831

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