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Article

SARS-CoV-2 neutralizing antibody specificities differ dramatically between recently infected infants and immune-imprinted individuals.

Journal of virology - 15 Apr 2025

Dadonaite Bernadeta, Burrell Allison R, Logue Jenni, Chu Helen Y, Payne Daniel C, Haslam David B, Staat Mary A, Bloom Jesse D

Abstract excerpt

The immune response to viral infection is shaped by past exposures to related virus strains, a phenomenon known as imprinting. For severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), much of the population has been imprinted by a viral spike from an early strain, either through vaccination or infection during the early stages of the COVID-19 pandemic. As a consequence of this imprinting, infection with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40130874
DOI: 10.1128/jvi.00109-25
PMCID: PMC11998527

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