Article
The Prognostic Impact of MLH1 Promoter Hypermethylation in Stage I-II Endometrial Cancer Treated With Adjuvant Radiation Therapy: A Multi-Institutional Retrospective Study.
International journal of radiation oncology, biology, physics - 1 Oct 2025
Sherwani Zohaib K, Damast Shari, Fields Emma C, Beriwal Sushil, Horne Zachary D, Kidd Elizabeth A, Leung Eric W, Taunk Neil K, Chino Junzo, Russo Andrea L, Dyer Michael, Albuquerque Kevin V, Hathout Lara
Abstract excerpt
PURPOSE: To assess the impact of MLH1 promoter hypermethylation (MLH1ph) on prognosis and define the patterns of recurrence in stage I or II endometroid endometrial cancer (EEC) treated with adjuvant radiation therapy. METHODS AND MATERIALS: In a retrospective, institutional review board-approved, multi-institutional cohort study, 814 patients with stage I or II EEC with known mismatch repair (MMR) status were...
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