Article
Epigenetic silencing of MLH1 in endometrial cancers is associated with larger tumor volume, increased rate of lymph node positivity and reduced recurrence-free survival.
Gynecologic oncology - 1 Sept 2017
Cosgrove Casey M, Cohn David E, Hampel Heather, Frankel Wendy L, Jones Dan, McElroy Joseph P, Suarez Adrian A, Zhao Weiqiang, Chen Wei, Salani Ritu, Copeland Larry J, O'Malley David M, Fowler Jeffrey M, Yilmaz Ahmet, Chassen Alexis S, Pearlman Rachel, Goodfellow Paul J, Backes Floor J
Abstract excerpt
OBJECTIVES: To determine the relationship between mismatch repair (MMR) classification and clinicopathologic features including tumor volume, and explore outcomes by MMR class in a contemporary cohort. METHODS: Single institution cohort evaluating MMR classification for endometrial cancers (EC). MMR immunohistochemistry (IHC)±microsatellite instability (MSI) testing and reflex MLH1 methylation testing was...
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