An Analysis of Clinical, Surgical, Pathological and Molecular Characteristics of Endometrial Cancer According to Mismatch Repair Status. A Multidisciplinary Approach.

doi:10.3390/ijms21197188

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Article

An Analysis of Clinical, Surgical, Pathological and Molecular Characteristics of Endometrial Cancer According to Mismatch Repair Status. A Multidisciplinary Approach.

International journal of molecular sciences - 29 Sept 2020

Dondi Giulia, Coluccelli Sara, De Leo Antonio, Ferrari Simona, Gruppioni Elisa, Bovicelli Alessandro, Godino Lea, Coadă Camelia Alexandra, Morganti Alessio Giuseppe, Giordano Antonio, Santini Donatella, Ceccarelli Claudio, Turchetti Daniela, De Iaco Pierandrea, Perrone Anna Myriam

Abstract excerpt

Since 2016, our hospital has applied tumor testing with immunohistochemistry (IHC) in endometrial cancer in order to detect mutations of mismatch repair genes (MMR). All cases with MMR deficiency proteins expression are sent for genetic testing, except those with MLH1 protein deficiency, in which case genetic testing is performed if negative for promoter hypermethylation. The primary aim of this study was to...

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PMID: 33003368
DOI: 10.3390/ijms21197188
PMCID: PMC7582893

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