Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mismatch repair protein and MLH1 methylation status as predictors of response to adjuvant therapy in endometrial cancer.

Cancer medicine - 1 Feb 2021

Loukovaara Mikko, Pasanen Annukka, Bützow Ralf

Abstract excerpt

BACKGROUND: Mismatch repair (MMR) system has been implicated in the response of mammalian cells to ionizing radiation and DNA damaging agents. We investigated the value of the MMR system in predicting response to adjuvant therapy in endometrial cancer. METHODS: This was a single institution retrospective study. MMR protein status of endometrial carcinomas was assessed by immunohistochemistry. MMR deficient...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Methylation
Share to DNA Mismatch Repair
Share to DNA Repair Enzymes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endometrial Neoplasms

Share to Follow-Up Studies

Share to Gene Expression Regulation, Neoplastic

Share to MutL Protein Homolog 1

Share to Survival Rate

Source

Open in PubMed Open full text

Identifiers

PMID: 33449452
DOI: 10.1002/cam4.3691
PMCID: PMC7897956

Genes

MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mismatch repair protein and MLH1 methylation status as predictors of response to adjuvant therapy in endometrial cancer.PMID 33449452Read ↗

Clinicopathologic Significance of Mismatch Repair Defects in Endometrial Cancer: An NRG Oncology/Gynecologic Oncology Group StudySemantic proximity Read ↗

Clinicopathologic significance of mismatch repair protein expression in endometrioid endometrial cancerSemantic proximity Read ↗

Clinicopathological characteristics of endometrial carcinomas according to DNA mismatch repair protein statusSemantic proximity Read ↗

The Prognostic Impact of MLH1 Promoter Hypermethylation in Stage I-II Endometrial Cancer Treated With Adjuvant Radiation Therapy: A Multi-Institutional Retrospective Study.Semantic proximity Read ↗

Updated evaluation of clinicopathologic landscape in histopathologic subtypes of endometrial carcinoma with MMR gene mutationSemantic proximity Read ↗

Updated evaluation of clinicopathologic landscape in histopathologic subtypes of endometrial carcinoma with MMR gene mutationSemantic proximity Read ↗

Mismatch Repair Deficiency as a Predictive and Prognostic Biomarker in Endometrial Cancer: A Review on Immunohistochemistry Staining Patterns and Clinical ImplicationsSemantic proximity Read ↗

Epigenetic silencing of MLH1 in endometrial cancers is associated with larger tumor volume, increased rate of lymph node positivity and reduced recurrence-free survival.Semantic proximity Read ↗

Clinicopathologic characteristics and outcomes of endometrial Cancer patients with mismatch repair deficiency in the era of universal Lynch syndrome screening.Semantic proximity Read ↗

Mismatch Repair Gene Deficiency in Ovarian Cancer: A Clinicopathological Analysis of MLH1, PMS2, MSH2, and MSH6 Mutations Across Histological Subtypes.Semantic proximity Read ↗

Differential outcomes and immune checkpoint inhibitor response among endometrial cancer patients with MLH1 hypermethylation versus MLH1 "Lynch-like" mismatch repair gene mutation.Semantic proximity Read ↗

Mismatch Repair Deficiency in Endometrial Cancer: Immunohistochemistry Staining and Clinical ImplicationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.