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Article

Traditional and New Views on MSI-H/dMMR Endometrial Cancer.

Biomolecules - 26 Sept 2025

Liu Chuqi, Ping Huiyu, Yao Mengmeng, Li Xinru, Li Qingxin, Hu Ruotong, Xu Yawen, Meng Kaidi, Gao Fei, Meng Kai

Abstract excerpt

MSI-H/dMMR endometrial cancer (EC) is closely linked to the mismatch repair (MMR) pathway, and its pathogenesis is associated with microsatellite instability (MSI) caused by abnormalities in the core genes of the conventional MMR system. This cancer exhibits a distinct immune microenvironment, which makes it suitable for treatment with immune checkpoint inhibitors (ICIs). This cancer type demonstrates...

Topics

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Colorectal Neoplasms, Hereditary Nonpolyposis
DNA Methylation
DNA Mismatch Repair
Endometrial Neoplasms
Immune Checkpoint Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microsatellite Instability

MutL Protein Homolog 1

Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 41154599
DOI: 10.3390/biom15101370
PMCID: PMC12562029

Genes

MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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