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Article

Murine norovirus allosteric escape mutants mimic gut activation.

Journal of virology - 17 Jun 2025

Sherman Michael B, Smith Hong Q, Cox Faith, Wobus Christiane E, Lynch Gillian C, Pettitt B Montgomery, Smith Thomas J

Abstract excerpt

Murine norovirus (MNV) undergoes large conformational changes in response to the environment. The T=3 icosahedral capsid is composed of 180 copies of ~58 kDa VP1 that has N-terminal (N), shell (S), and C-terminal protruding (P) domains. In phosphate-buffered saline, the P domains are loosely tethered to the shell and float ~15 Å above the surface. At conditions found in the gut (i.e., low pH with high metal ion...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 40353669
DOI: 10.1128/jvi.00219-25
PMCID: PMC12172446

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