Article
Dynamic rotation of the protruding domain enhances the infectivity of norovirus
2019-12-17
Abstract excerpt
Norovirus is the major cause of epidemic nonbacterial gastroenteritis worldwide. Lack of structural information on infection and replication mechanisms hampers the development of effective vaccines and remedies. Here, using cryo-electron microscopy, we show that the capsid structure of murine noroviruses changes in response to aqueous conditions. By twisting the flexible hinge connecting two domains, the protrudin...
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Identifiers and source
- Literature Corpus work
- 15d2f52b-ec9e-5b6f-ae0a-58ef38b1bb61
- DOI
- 10.1101/2019.12.16.878785