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Article

Gastric cancer cells shuttle lactate to induce inflammatory CAF-like phenotype and function in bone marrow-derived mesenchymal stem cells.

Molecular immunology - 1 Jul 2025

Huang Feng, Cao Xiaoli, Mei Jingyu, Wu Chen, Zhu Wei, Sun Li, Dai Chun, Wang Mei

Abstract excerpt

Metabolic reprogramming, exemplified by the "Warburg effect," is a hallmark of human cancers, leading to lactate buildup in tumors. Bone marrow-derived mesenchymal stem cells (BM-MSCs), key contributors to cancer-associated fibroblasts (CAFs), integrate into gastric cancer stroma through interactions with cancer cells. However, the role of lactate in activating BM-MSCs in this context remains unclear. Herein,...

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PMID: 40347782
DOI: 10.1016/j.molimm.2025.05.002

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