SFRP2+ CAFs Expressing Myofibroblastic Phenotype Are Involved in Glutamine Metabolism and Malignant Behaviors of Laryngeal Squamous Cell Carcinoma by Collaborating With ELAVL1 to Stabilize GID8 mRNA.

doi:10.1002/mc.70138

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SFRP2+ CAFs Expressing Myofibroblastic Phenotype Are Involved in Glutamine Metabolism and Malignant Behaviors of Laryngeal Squamous Cell Carcinoma by Collaborating With ELAVL1 to Stabilize GID8 mRNA.

Molecular carcinogenesis - 1 Oct 2026

Pang Bo, Zhang Ying

Abstract excerpt

Metabolic reprogramming is a hallmark of cancer, enabling tumor cells to meet the demands of rapid growth and survival. Within tumor microenvironment (TME), cancer-associated fibroblasts (CAFs) influence tumor metabolism through metabolic crosstalk. However, role of CAF-derived factors in regulating glutamine metabolism in laryngeal squamous cell carcinoma (LSCC) remains unclear. Primary fibroblasts were isolated...

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Topics

Humans
Glutamine
Cancer-Associated Fibroblasts
Laryngeal Neoplasms
Gene Expression Regulation, Neoplastic
Metabolic Reprogramming

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Membrane Proteins

Cell Proliferation

RNA, Messenger

Carcinoma, Squamous Cell

Cell Line, Tumor

Cell Movement

Tumor Microenvironment

Phenotype

ELAV-Like Protein 1

Source

Open in PubMed Open full text

Identifiers

PMID: 42472387
DOI: 10.1002/mc.70138
PMCID: PMC13576741

Genes

SFRP2
ELAVL1
GID8
CCK
RTCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

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