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Article

Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts

30 Oct 2019

Abstract excerpt

Even though pancreatic ductal adenocarcinoma (PDAC) is associated with fibrotic stroma, the molecular pathways regulating the formation of cancer associated fibroblasts (CAFs) are not well elucidated. An epigenomic analysis of patient-derived and de-novo generated CAFs demonstrated widespread loss of cytosine methylation that was associated with overexpression of various inflammatory transcripts including CXCR4....

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PMID: 31663852
DOI: 10.7554/elife.50663

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