Genetic Architecture and Risk of Childhood Maltreatment Across 5 Psychiatric Diagnoses.

doi:10.1001/jamapsychiatry.2025.0828

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Article

Genetic Architecture and Risk of Childhood Maltreatment Across 5 Psychiatric Diagnoses.

JAMA psychiatry - 1 Aug 2025

Nielsen Trine Tollerup, Bali Paraskevi, Grove Jakob, Mohr-Jensen Christina, Werge Thomas, Dalsgaard Søren, Børglum Anders D, Sonuga-Barke Edmund, Minnis Helen, Demontis Ditte, Corfield Elizabeth C, Tbartz van Elst Ludger, Mattheisen Manuel, de Wit Melanie M, Uddin Mohammed Jashim, Anney Richard J L, Scherer Stephen W, Bourgeron Thomas, Polderman Tinca J C

Abstract excerpt

Importance: Childhood maltreatment (CM) is associated with psychiatric disorders. The underlying mechanisms are complex and involve genetics. Objective: To investigate the polygenic architecture of CM-exposed individuals across psychiatric conditions and if genetics modulates absolute CM risk in the presence of high-impact risk factors such as parental psychiatric diagnoses. Design, Setting, and Participants: The...

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PMID: 40341348
DOI: 10.1001/jamapsychiatry.2025.0828
PMCID: PMC12065082

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