Article
Estimating the impact of transmitted and non-transmitted psychiatric and neurodevelopmental polygenic scores on youth emotional problems.
Molecular psychiatry - 1 Feb 2024
Shakeshaft Amy, Martin Joanna, Dennison Charlotte A, Riglin Lucy, Lewis Cathryn M, O'Donovan Michael C, Thapar Anita
Abstract excerpt
Anxiety and depression (emotional disorders) are familial and heritable, especially when onset is early. However, other cross-generational studies suggest transmission of youth emotional problems is explained by mainly environmental risks. We set out to test the contribution of parental non-transmitted genetic liability, as indexed by psychiatric/neurodevelopmental common polygenic liability, to youth emotional...
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