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Article

Specificity of Polygenic Scores for Psychiatric Disorders Beyond Transdiagnostic Genetic Risk.

JAMA network open - 2 Jan 2026

Keser Engin, Liao Wangjingyi, Allegrini Andrea G, Eley Thalia C, Rimfeld Kaili, Malanchini Margherita, Plomin Robert

Abstract excerpt

Importance: Polygenic scores (PGSs) are increasingly used to estimate genetic liability for psychiatric disorders, but their limited disorder specificity constrains their clinical and research utility. Objective: To test whether associations between psychiatric PGSs and psychiatric outcomes are primarily driven by transdiagnostic or disorder-specific genetic liability. Design, Setting, and Participants: This...

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Identifiers

PMID: 41505135
DOI: 10.1001/jamanetworkopen.2025.48518
PMCID: PMC12784231

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