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Article

Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer.

Nature - 1 Jan 2000

Ohashi P S, Mak T W, Van den Elsen P, Yanagi Y, Yoshikai Y, Calman A F, Terhorst C, Stobo J D, Weiss A

Abstract excerpt

We have introduced a full-length complementary DNA of the T-cell antigen receptor beta-chain into a mutant human T-cell line that lacked a complete beta-chain messenger RNA, had a diminished level of alpha-chain transcript and did not express surface T3- or antigen receptor. Expression of the transfected beta-chain led to a normal level of alpha-chain transcript and a structurally and functionally active T3...

Topics

Cell Line
DNA
Humans
Mutation
Proteins
RNA, Messenger
Receptors, Antigen, T-Cell
Transcription, Genetic
Transformation, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 4033759
DOI: 10.1038/316606a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-4033759-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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