Article
Expression and function of gamma delta- and alpha beta-T cell receptor heterodimers on human somatic T cell hybrids.
Journal of immunology (Baltimore, Md. : 1950) - 15 May 1990
Kozbor D, Cassatella M A, Lessin S, Kagan J, Finver S, Faust J, Trinchieri G, Croce C M
Abstract excerpt
T cell somatic hybrids were obtained by fusion of human tetanus toxoid-specific gamma + delta + T cells and a T cell lymphoma cell line that expresses beta-chain but not alpha-chain transcripts. The hybrids simultaneously and independently expressed alpha beta and gamma delta TCR heterodimers on...
Topics
- Alleles
- Blotting, Northern
- Blotting, Southern
- Epitopes
- Flow Cytometry
- Gene Expression
- Humans
- Hybrid Cells
- Receptors, Antigen, T-Cell
- Receptors, Antigen, T-Cell, alpha-beta
- Receptors, Antigen, T-Cell, gamma-delta
- Receptors, Interleukin-2
- Signal Transduction
- T-Lymphocytes