Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide Pleiotropy Analysis Reveals Shared Genetic Associations between Type 2 Diabetes Mellitus and Subcortical Brain Volumes

1 Jan 2025

Abstract excerpt

Type 2 diabetes mellitus (T2DM), a prevalent metabolic disorder marked by insulin resistance and hyperglycemia, has been linked to volumetric changes in subcortical regions, yet the genetic basis of this relationship remains unclear. We analyzed genome-wide association study summary data for T2DM and 14 subcortical volumetric traits, using MiXeR to quantify shared genetic architecture and applying...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diet and metabolism studies
Share to Neurological Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40330659
DOI: 10.34133/research.0688

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide Pleiotropy Analysis Reveals Shared Genetic Associations between Type 2 Diabetes Mellitus and Subcortical Brain VolumesPMID 40330659Read ↗

Investigating the shared genetic architecture between depression and subcortical volumes.Semantic proximity Read ↗

Shared Genetic Architecture and Causal Relationship Between Diabetes, Glycemic Traits, and Cerebral Small Vessel DiseaseSemantic proximity Read ↗

Mapping genetic convergence across brain structure, mental health, and cardiometabolic diseaseSemantic proximity Read ↗

Shared genetic architecture between schizophrenia and subcortical brain volumes implicates early neurodevelopmental processes and brain development in childhood.Semantic proximity Read ↗

Shared Genetic Underpinnings of Gray Matter Volume Alterations and Metabolic Traits in Major Depressive DisorderSemantic proximity Read ↗

A novel morphometric signature of brain alterations in type 2 diabetes: patterns of changed cortical gyrificationSemantic proximity Read ↗

A latent clinical-anatomical dimension relating metabolic syndrome to brain structure and cognitionSemantic proximity Read ↗

The expression of insulin signaling and N-methyl-D-aspartate receptor genes in areas of gray matter atrophy is associated with cognitive function in type 2 diabetesSemantic proximity Read ↗

Heritability and genetic association analysis of neuroimaging measures in the Diabetes Heart Study.Semantic proximity Read ↗

Shared genetic and neuroimmune architecture links type 1 diabetes with neurocognitive traits.Semantic proximity Read ↗

Causal Links of Type 2 Diabetes and Its Complications With Cortical Modification: A Mendelian Randomization and Mediation Analysis.Semantic proximity Read ↗

Effects of polygenic risk score of type 2 diabetes on the hippocampal topological property and episodic memorySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.