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Article

Assessing Microprocessor complex mutations with a Microsensor system.

RNA (New York, N.Y.) - 16 Jun 2025

Bao Sheng, Le Thi Nhu-Y, Le Cong Truc, Tran Le Nguyen Bao, Nguyen Tuan Anh

Abstract excerpt

The Microprocessor complex, consisting of DROSHA and DGCR8, is essential for miRNA maturation and gene regulation. Mutations in these proteins are associated with Wilms tumor (WiT), a common pediatric kidney cancer. To explore the impact of these mutations on WiT pathogenesis, we developed the Microsensor system, a novel tool for dynamically monitoring Microprocessor activity in human cells. Using this system, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40328469
DOI: 10.1261/rna.080338.124
PMCID: PMC12170184

Genes

DGCR8
DROSHA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

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Research trail→

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Assessing Microprocessor complex mutations with a Microsensor system.PMID 40328469Read ↗

The DGCR8 E518K mutation found in Wilms tumors leads to a partial miRNA processing defect that alters gene expression patterns and biological processes.Semantic proximity Read ↗

Recurrent somatic mutation in DROSHA induces microRNA profile changes in Wilms tumour.Semantic proximity Read ↗

DGCR8 microprocessor defect characterizes familial multinodular goiter with schwannomatosis.Semantic proximity Read ↗

Partial Disturbance of Microprocessor Function in Human Stem Cells Carrying a Heterozygous Mutation in the DGCR8 Gene.Semantic proximity Read ↗

DROSHA Regulates Mesenchymal Gene Expression in Wilms Tumor.Semantic proximity Read ↗

Mismatched and wobble base pairs govern primary microRNA processing by human Microprocessor.Semantic proximity Read ↗

Cancer-associated somatic DICER1 hotspot mutations cause defective miRNA processing and reverse-strand expression bias to predominantly mature 3p strands through loss of 5p strand cleavage.Semantic proximity Read ↗

Comparative Biochemical Studies of Disease-Associated Human Dicer Mutations on Processing of a Pre-microRNA and snoRNA.Semantic proximity Read ↗

The structural landscape of Microprocessor mediated pri- <i>let-7</i> miRNA processingSemantic proximity Read ↗

Human disease-associated single nucleotide polymorphism changes the orientation of DROSHA on pri-mir-146a.Semantic proximity Read ↗

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