Article
Recurrent somatic mutation in DROSHA induces microRNA profile changes in Wilms tumour.
Nature communications - 9 Jun 2014
Torrezan Giovana T, Ferreira Elisa N, Nakahata Adriana M, Barros Bruna D F, Castro Mayra T M, Correa Bruna R, Krepischi Ana C V, Olivieri Eloisa H R, Cunha Isabela W, Tabori Uri, Grundy Paul E, Costa Cecilia M L, de Camargo Beatriz, Galante Pedro A F, Carraro Dirce M
Abstract excerpt
Wilms tumour (WT) is an embryonal kidney neoplasia for which very few driver genes have been identified. Here we identify DROSHA mutations in 12% of WT samples (26/222) using whole-exome sequencing and targeted sequencing of 10 microRNA (miRNA)-processing genes. A recurrent mutation (E1147K) affecting a metal-binding residue of the RNase IIIb domain is detected in 81% of the DROSHA-mutated tumours. In addition,...
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