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Article

DROSHA Regulates Mesenchymal Gene Expression in Wilms Tumor.

Molecular cancer research : MCR - 2 Aug 2024

Tiburcio Patricia D B, Desai Kavita, Kim Jiwoong, Zhou Qinbo, Guo Lei, Xiao Xue, Zhou Li, Yuksel Aysen, Catchpoole Daniel R, Amatruda James F, Xu Lin, Chen Kenneth S

Abstract excerpt

Wilms tumor, the most common pediatric kidney cancer, resembles embryonic renal progenitors. Currently, there are no ways to therapeutically target Wilms tumor driver mutations, such as in the microRNA processing gene DROSHA. In this study, we used a "multiomics" approach to define the effects of DROSHA mutation in Wilms tumor. We categorized Wilms tumor mutations into four mutational subclasses with unique...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38647377
DOI: 10.1158/1541-7786.MCR-23-0930
PMCID: PMC11296922

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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