Article
A Mendelian randomization study of the association between serum uric acid and osteoporosis risk.
Frontiers in endocrinology - 1 Jan 2024
Wu Heng, Li Hairui, Dai Xiao, Dai Yu, Liu Hao, Xu Shuang, Huang Jinbang, Chi Hao, Wang Song
Abstract excerpt
Background: The relationship between serum uric acid (SUA) and osteoporosis (OP) has yielded conflicting results in observational studies. This Mendelian randomization (MR) study aims to elucidate the causal association between SUA and OP. Methods: A two-sample MR analysis was conducted using summary-level data from genome-wide association studies (GWAS). Two sets of polygenic instruments strongly associated (p <...
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