CHIP and hips: clonal hematopoiesis is common in patients undergoing hip arthroplasty and is associated with autoimmune disease.

doi:10.1182/blood.2020010163

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Article

CHIP and hips: clonal hematopoiesis is common in patients undergoing hip arthroplasty and is associated with autoimmune disease.

Blood - 4 Nov 2021

Hecker Judith S, Hartmann Luise, Rivière Jennifer, Buck Michèle C, van der Garde Mark, Rothenberg-Thurley Maja, Fischer Luise, Winter Susann, Ksienzyk Bianka, Ziemann Frank, Solovey Maria, Rauner Martina, Tsourdi Elena, Sockel Katja, Schneider Marie, Kubasch Anne S, Nolde Martin, Hausmann Dominikus, Paulus Alexander C, Lützner Jörg, Roth Andreas, Bassermann Florian, Spiekermann Karsten, Marr Carsten, Hofbauer Lorenz C, Platzbecker Uwe, Metzeler Klaus H, Götze Katharina S

Abstract excerpt

Clonal hematopoiesis (CH) is an age-related condition predisposing to blood cancer and cardiovascular disease (CVD). Murine models demonstrate CH-mediated altered immune function and proinflammation. Low-grade inflammation has been implicated in the pathogenesis of osteoarthritis (OA), the main indication for total hip arthroplasty (THA). THA-derived hip bones serve as a major source of healthy hematopoietic...

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PMID: 34139005
DOI: 10.1182/blood.2020010163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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