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Article

Epigenetic alterations in rheumatoid arthritis: multilayer mechanisms and translational opportunities.

Frontiers in immunology - 1 Jan 2026

Podgórska Dominika, Podgórski Rafał

Abstract excerpt

Rheumatoid arthritis (RA) is a chronic inflammatory disease driven by immune dysregulation, in which genetic susceptibility and environmental exposures promote persistent synovitis, progressive joint damage, and systemic comorbidities. Recent epigenomic studies show several recurring abnormalities. Many RA susceptibility variants lie outside protein-coding sequence and map to immune-cell and synovial fibroblast...

Read the complete abstract on PubMed

Topics

Humans
Arthritis, Rheumatoid
Epigenesis, Genetic
DNA Methylation
Genetic Predisposition to Disease
Animals
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

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Identifiers

PMID: 42746461
DOI: 10.3389/fimmu.2026.1871766
PMCID: PMC13576145

Genes

TET3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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