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Bayesian Inference of Phenotypic Plasticity of Cancer Cells Based on Dynamic Model for Temporal Cell Proportion Data.

Biometrical journal. Biometrische Zeitschrift - 1 Jun 2025

Chen Shuli, Wang Yuman, Da Zhou, Hu Jie

Abstract excerpt

Mounting evidence underscores the prevalent hierarchical organization of cancer tissues. At the foundation of this hierarchy reside cancer stem cells, a subset of cells endowed with the pivotal role of engendering the entire cancer tissue through cell differentiation. In recent times, substantial attention has been directed toward the phenomenon of cancer cell plasticity, where the dynamic interconversion between...

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PMID: 40298362
DOI: 10.1002/bimj.70055

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