Article
The accuracy of polygenic score models for BMI and Type II diabetes in the Native Hawaiian population.
Communications biology - 23 Apr 2025
Lo Ying-Chu, Tian He, Chan Tsz Fung, Jeon Soyoung, Alatorre Kimberli, Dinh Bryan L, Maskarinec Gertraud, Taparra Kekoa, Nakatsuka Nathan, Yu Mingrui, Chen Chia-Yen, Lin Yen-Feng, Wilkens Lynne R, Le Marchand Loic, Haiman Christopher A, Chiang Charleston W K
Abstract excerpt
Polygenic scores (PGS) are promising in stratifying individuals based on the genetic susceptibility to complex diseases or traits. However, the accuracy of PGS models, typically trained in European- or East Asian-ancestry populations, tend to perform poorly in other ethnic minority populations and their accuracies have not been evaluated for Native Hawaiians. In particular, for body mass index (BMI) and type-2...
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