Substrate-specificity of pharmacogenomic variability - clinical relevance and emerging predictive strategies.

Abstract excerpt

INTRODUCTION: Genetic variation in drug-metabolizing enzymes and transporters contributes to interindividual differences in drug efficacy and toxicity. While current pharmacogenomic practice typically assigns fixed functional categories to variant alleles, accumulating evidence shows that many variant alleles exert substrate-specific effects. AREAS COVERED: We here summarize the current evidence for...

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