Article
Haemophilus influenzae Glucose Catabolism Leading to Production of the Immunometabolite Acetate Has a Key Contribution to the Host Airway-Pathogen Interplay.
ACS infectious diseases - 13 Mar 2020
López-López Nahikari, Euba Begoña, Hill Julian, Dhouib Rabeb, Caballero Lucı A, Leiva José, Hosmer Jennifer, Cuesta Sergio, Ramos-Vivas José, Díez-Martínez Roberto, Schirra Horst Joachim, Blank Lars M, Kappler Ulrike, Garmendia Junkal
Abstract excerpt
Chronic obstructive pulmonary disease (COPD) is characterized by abnormal inflammatory responses and impaired airway immunity, which provides an opportunistic platform for nontypeable Haemophilus influenzae (NTHi) infection. Clinical evidence supports that the COPD airways present increased concentrations of glucose, which may facilitate proliferation of pathogenic bacteria able to use glucose as a carbon source....
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