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Article

Risk of lymphoid malignancy associated with cancer predisposition genes.

Blood cancer journal - 19 Apr 2025

Boddicker Nicholas J, Mwangi Raphael, Robinson Dennis P, Allmer Cristine, Rosenthal Allison C, Habermann Thomas M, Feldman Andrew L, Rimsza Lisa M, King Rebecca L, Larson Melissa C, Negaard Bri J, Norman Aaron D, Rajkumar Nikhil, Ansell Stephen M, Dispenzieri Angela, Murray David L, Rajkumar Vincent, Kumar Shaji, Abeykoon Jithma P, Nowakowski Grzegorz S, Witzig Thomas E, Novak Anne J, Slager Susan L, Vachon Celine M, Cerhan James R

Abstract excerpt

We investigated the prevalence of rare inherited pathogenic variants (PV) in 19 cancer predisposition genes regularly included on multi-gene panel testing based on NCCN guidelines and their association with the risk of lymphoid malignancies (LM) overall and by common lymphoma subtypes and multiple myeloma. The study population included newly diagnosed LM cases (N = 6990) and unrelated controls (N = 42,632),...

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Identifiers

PMID: 40253392
DOI: 10.1038/s41408-025-01283-z
PMCID: PMC12009404

Genes

ATM
CHEK2
BRCA1
BRCA2
TP53

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